CortexBio Insights — Rare Disease & Metabolic Health Research

Diagram illustrating pavement camber angle and its effect on knee joint loading

Pulse

263,865 joint replacements. An NHS waiting list over 800,000. Britain's crumbling pavements tilt beyond legal limits — loading knees asymmetrically with every step. Dr Dima Martini-Drew MD on the infrastructure variable medicine has overlooked.

263,865 joint replacements across England, Wales and Northern Ireland in a single year. An NHS waiting list of more than 800,000 people for trauma and orthopaedic care.

Pro

How asymmetric loading from cambered pavements drives molecular ageing: the biological cascade, evidence from 18 peer-reviewed studies, and the NHS waiting-time data. Clinical layer by Dr Dima Martini-Drew MD.

263,865 joint replacements in a single year. The clinical evidence connecting Britain’s pavement cambers to measurable acceleration of joint degeneration.

Insider

Cambered pavements as a chronic metabolic stressor: the complete molecular cascade from asymmetric joint loading to systemic ageing markers, intervention timing, and the clinical framework. By Dr Dima Martini-Drew MD.

What happens when you trace the biomechanical insult of environmental gradients all the way through to its metabolic and epigenetic consequences. The answer implicates infrastructure policy as a direct determinant of biological ageing.

Original research and analysis on rare disease, metabolic health, and the biology of ageing. By Dima Martini-Drew MD, physician-scientist and founder of CortexBio.

Latest

263,865 joint replacements. An NHS waiting list over 800,000. Britain's crumbling pavements tilt beyond legal limits — loading knees asymmetrically with every step. Dr Dima Martini-Drew MD on the infrastructure variable medicine has overlooked.

How asymmetric loading from cambered pavements drives molecular ageing: the biological cascade, evidence from 18 peer-reviewed studies, and the NHS waiting-time data. Clinical layer by Dr Dima Martini-Drew MD.

Cambered pavements as a chronic metabolic stressor: the complete molecular cascade from asymmetric joint loading to systemic ageing markers, intervention timing, and the clinical framework. By Dr Dima Martini-Drew MD.